Stressing Out PanIN: NRF2 Pushes over the Edge

Laura Torrente; Gina M DeNicola

doi:10.1016/j.ccell.2017.11.014

Stressing Out PanIN: NRF2 Pushes over the Edge

Cancer Cell. 2017 Dec 11;32(6):723-725. doi: 10.1016/j.ccell.2017.11.014.

Authors

Laura Torrente¹, Gina M DeNicola²

Affiliations

¹ Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
² Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: gina.denicola@moffitt.org.

PMID: 29232549
DOI: 10.1016/j.ccell.2017.11.014

Abstract

The mechanisms by which chronic stress promote the development of pancreatic ductal adenocarcinoma (PDAC) are poorly defined. In this issue of Cancer Cell, Todoric et al. discover a role for impaired autophagy in the development of PDAC through p62-mediated activation of NRF2.

Publication types

Comment

MeSH terms

Carcinoma in Situ*
Carcinoma, Pancreatic Ductal*
Humans
NF-E2-Related Factor 2
Pancreas
Pancreatic Neoplasms*
Proto-Oncogene Proteins c-mdm2

Substances

NF-E2-Related Factor 2
MDM2 protein, human
Proto-Oncogene Proteins c-mdm2