Responsive DNA G-quadruplex micelles

Chem Commun (Camb). 2018 Jan 2;54(3):260-263. doi: 10.1039/c7cc07899d.

Abstract

A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Animals
  • Aptamers, Nucleotide / genetics
  • Carbocyanines / chemistry
  • Cattle
  • DNA / chemistry*
  • DNA / genetics
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Fluorescent Dyes / chemistry
  • G-Quadruplexes*
  • Lipids / chemistry*
  • Micelles
  • Nucleic Acid Hybridization
  • Oxazines / chemistry
  • Serum Albumin, Bovine / chemistry

Substances

  • Aptamers, Nucleotide
  • Carbocyanines
  • Drug Carriers
  • Fluorescent Dyes
  • Lipids
  • Micelles
  • Oxazines
  • Serum Albumin, Bovine
  • 3,3'-dioctadecylindocarbocyanine
  • 3,3'-dioctadecyloxacarbocyanine
  • Adenosine Triphosphate
  • DNA
  • nile red