Dynamic functional disturbances of brain network in seizure-related cognitive outcomes

Jialing Guo; Qian Wu; Charlie W Zhao; Bo Xiao; Li Feng

doi:10.1016/j.eplepsyres.2017.12.005

Dynamic functional disturbances of brain network in seizure-related cognitive outcomes

Epilepsy Res. 2018 Feb:140:15-21. doi: 10.1016/j.eplepsyres.2017.12.005. Epub 2017 Dec 5.

Authors

Jialing Guo¹, Qian Wu², Charlie W Zhao³, Bo Xiao¹, Li Feng⁴

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
² Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan, 650032, China.
³ Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.
⁴ Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. Electronic address: fenglihx@163.com.

PMID: 29227796
DOI: 10.1016/j.eplepsyres.2017.12.005

Abstract

Epilepsy is a prevalent neurologic disorder affecting approximately 50 million people worldwide. Cognitive dysfunction induced by seizures is one of the severe comorbidities of epilepsy and epileptic syndrome, which has a negative impact on epileptic patients' quality of life. Several mechanisms may be associated with cognitive impairment in patients with epilepsy. Here, we review how the dynamic functional alterations of brain network influence seizure-related cognitive outcomes.

Keywords: Blood oxygen level-dependent (BOLD); Cognition; Epilepsy; Interictal epileptiform discharges (IEDs); Seizure; Spikes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / physiopathology*
Cognition / physiology*
Cognition Disorders / etiology*
Cognition Disorders / physiopathology*
Humans
Seizures / complications
Seizures / physiopathology*
Seizures / psychology*