Immunometabolism in 2017: Driving immunity: all roads lead to metabolism

Edward J Pearce; Erika L Pearce

doi:10.1038/nri.2017.139

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism

Nat Rev Immunol. 2018 Feb;18(2):81-82. doi: 10.1038/nri.2017.139. Epub 2017 Dec 11.

Authors

Edward J Pearce¹, Erika L Pearce²

Affiliations

¹ Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany; and at the Faculty of Biology, University of Freiburg, Freiburg, Germany.
² Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

Abstract

In 2017, studies of cellular metabolism broadly permeated immunological research. Accumulating data support the view that understanding how metabolism regulates immune cell function could provide new therapeutic opportunities for the many diseases associated with immune system dysregulation.

Publication types

Introductory Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Glycolysis / immunology
Host Microbial Interactions / immunology
Humans
Immune System / metabolism*
Killer Cells, Natural / immunology
Killer Cells, Natural / metabolism
Microbiota / immunology
Microglia / immunology
Microglia / metabolism
Models, Immunological
T-Lymphocytes / immunology
T-Lymphocytes / metabolism

Grants and funding

R01 CA181125/CA/NCI NIH HHS/United States