Natural aldehyde extraction and direct preparation of new blue light-emitting imidazo[1,5-a]pyridine fluorophores

Nat Prod Res. 2018 Oct;32(19):2304-2311. doi: 10.1080/14786419.2017.1410803. Epub 2017 Dec 11.

Abstract

This work describes the extraction of natural aldehydes and the use of extracts to synthesise new fluorescent imidazo[1,5-a]pyridine derivatives. The characterisation of the extracted aldehydes by different techniques and the optical study of the fluorescent products allow the design of new compounds suitable for pharmaceutical, down-shifting, microscopy and electronic applications. The fluorophores are generated by an easy one-pot cyclisation reaction in mild conditions without catalyst and with only water as by-product.

Keywords: Imidazo[1,5-a]pyridine; UV absorption; blue emitters; fluorescence; large Stokes’ shift.

MeSH terms

  • Aldehydes / chemistry
  • Aldehydes / isolation & purification*
  • Color
  • Cyclization
  • Drug Design
  • Fluorescent Dyes / chemical synthesis*
  • Pyridines / chemical synthesis*
  • Water

Substances

  • Aldehydes
  • Fluorescent Dyes
  • Pyridines
  • Water