Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

Cancer Metastasis Rev. 2018 Mar;37(1):147-157. doi: 10.1007/s10555-017-9711-z.

Abstract

G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical and structural analyses have immensely enhanced our knowledge of GPCR involvement in health and disease states. The present review focuses on GPCRs that are cancer drivers, involved in tumor growth and development. Our aim is to highlight the involvement of stabilized β-catenin molecular machinery with a specific array of GPCRs. We discuss recent advances in understanding the molecular path leading to β-catenin nuclear localization and transcriptional activity and their implications for future cancer therapy research.

Keywords: Cancer; G protein-coupled receptors; β-catenin.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelins / metabolism
  • Hippo Signaling Pathway
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Serine-Threonine Kinases / metabolism
  • Protein Stability
  • Protein Transport
  • Receptor, Parathyroid Hormone, Type 1 / metabolism
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, Lysophosphatidic Acid / metabolism
  • Receptors, Prostaglandin / metabolism
  • Signal Transduction
  • Transcription, Genetic
  • Wnt Signaling Pathway
  • beta Catenin / metabolism*

Substances

  • Endothelins
  • LGR5 protein, human
  • Receptor, Parathyroid Hormone, Type 1
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Receptors, Prostaglandin
  • beta Catenin
  • Protein Serine-Threonine Kinases