Efficacy and harms of pharmacological interventions for neurobehavioral symptoms in post traumatic amnesia after traumatic brain injury: a systematic review and meta-analysis protocol

Amelia J Hicks; Fiona J Clay; Malcolm Hopwood; Mahesh Jayaram; Rachel Batty; Jennie L Ponsford

doi:10.11124/JBISRIR-2017-003430

Efficacy and harms of pharmacological interventions for neurobehavioral symptoms in post traumatic amnesia after traumatic brain injury: a systematic review and meta-analysis protocol

JBI Database System Rev Implement Rep. 2017 Dec;15(12):2890-2912. doi: 10.11124/JBISRIR-2017-003430.

Authors

Amelia J Hicks¹, Fiona J Clay^{2

3

4}, Malcolm Hopwood^{2

5}, Mahesh Jayaram², Rachel Batty², Jennie L Ponsford¹

Affiliations

¹ Monash-Epworth Rehabilitation Research Centre, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia.
² Department of Psychiatry, University of Melbourne, Melbourne, Australia.
³ Department of Forensic Medicine, Monash University, Southbank, Australia.
⁴ The Australian Centre for Evidence-Based Primary Health Care, Community Care: a Joanna Briggs Institute Centre of Excellence, Adelaide, Australia.
⁵ Professorial Psychiatry Unit, Albert Road Clinic, Department of Psychiatry, University of Melbourne, Melbourne, Australia.

PMID: 29219873
DOI: 10.11124/JBISRIR-2017-003430

Abstract

The objective of this systematic review is to synthesize the best available evidence on the effectiveness and harms of pharmacotherapy as compared to all types of comparators for the management of neurobehavioral symptoms in post-traumatic amnesia in adults aged 16 years and over who have sustained a traumatic brain injury. This review forms part of a larger project which aims to gather the evidence for the pharmacological treatment of neurobehavioral symptoms post traumatic brain injury as a prelude to the development of a clinical guideline.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amnesia* / drug therapy
Amnesia* / etiology
Brain Injuries, Traumatic* / complications
Brain Injuries, Traumatic* / psychology
Clinical Protocols
Humans
Meta-Analysis as Topic
Psychotropic Drugs* / therapeutic use
Systematic Reviews as Topic
Treatment Outcome

Substances

Psychotropic Drugs