Cu(II)-Mediated Decarboxylative Trifluoromethylthiolation of α,β-Unsaturated Carboxylic Acids

Zhi-Fei Cheng; Ting-Ting Tao; Yi-Si Feng; Wei-Ke Tang; Jun Xu; Jian-Jun Dai; Hua-Jian Xu

doi:10.1021/acs.joc.7b02232

Cu(II)-Mediated Decarboxylative Trifluoromethylthiolation of α,β-Unsaturated Carboxylic Acids

J Org Chem. 2018 Jan 5;83(1):499-504. doi: 10.1021/acs.joc.7b02232. Epub 2017 Dec 15.

Authors

Zhi-Fei Cheng¹, Ting-Ting Tao¹, Yi-Si Feng^{1

2}, Wei-Ke Tang¹, Jun Xu³, Jian-Jun Dai³, Hua-Jian Xu^{1

3}

Affiliations

¹ Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology , Hefei 230009, P. R. China.
² Anhui Provincial Laboratory of Heterocyclic Chemistry , Maanshan 243110, P. R. China.
³ School of Biological and Medical Engineering, Hefei University of Technology , Hefei 230009, P. R. China.

PMID: 29214800
DOI: 10.1021/acs.joc.7b02232

Abstract

A tunable method for the direct trifluoromethylthiolation of α,β-unsaturated carboxylic acids was developed to afford trifluoromethylthiolated ketones or alkenes. The reaction proceeds smoothly under mild conditions and shows an excellent functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't