Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives

Yu Yi; Gan Lin; Shaoyi Chen; Jing Liu; Huaping Zhang; Peng Mi

doi:10.1016/j.msec.2017.10.004

Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives

Mater Sci Eng C Mater Biol Appl. 2018 Feb 1:83:218-232. doi: 10.1016/j.msec.2017.10.004. Epub 2017 Oct 5.

Authors

Yu Yi¹, Gan Lin², Shaoyi Chen³, Jing Liu³, Huaping Zhang³, Peng Mi⁴

Affiliations

¹ Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Number 17, 3rd Section, Renmin South Road, Chengdu, Sichuan 610041, China; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
² State Key Laboratory of Molecular Vaccinology, Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
³ Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Number 17, 3rd Section, Renmin South Road, Chengdu, Sichuan 610041, China.
⁴ Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Number 17, 3rd Section, Renmin South Road, Chengdu, Sichuan 610041, China. Electronic address: mi@scu.edu.cn.

PMID: 29208282
DOI: 10.1016/j.msec.2017.10.004

Abstract

The development of tumor-targeting nanocarriers is critical important for effective treatment. The synthetic polyesters have demonstrated high potential for developing nanocarriers for cancer theranostics. Especially, the biocompatible and biodegradable polyester micelles have held great promise for cancer therapy and diagnosis, while some candidates have been translated into clinical applications or under clinical trial. In this review, we have provided the state-of-the-art of polyester micelles for drug delivery and cancer theranostics. In addition, we have summarized several major types of polyesters used in the biomedical fields, the current clinical achievements of polyester micelles and recent progresses of multi-functional polyester micelles for tumor molecular imaging and therapeutic applications.

Keywords: Cancer therapy; Drug delivery systems; Micelle; Polyester; Theranostics.

Publication types

Review

MeSH terms

Drug Carriers / chemistry
Drug Delivery Systems / methods
Micelles
Neoplasms / drug therapy
Polyesters / chemistry*
Polymers / chemistry
Theranostic Nanomedicine / methods

Substances

Drug Carriers
Micelles
Polyesters
Polymers