Progress towards a vaccine against Ebola to meet emergency medical countermeasure needs

Vaccine. 2019 Nov 15;37(48):7178-7182. doi: 10.1016/j.vaccine.2017.10.111. Epub 2017 Dec 2.

Abstract

The Ebola virus epidemic in West Africa proved to be the largest in the history of filovirus outbreaks, causing the World Health Organization to declare a public health emergency of international concern in August of 2014. In collaboration with domestic and international partners, the Biomedical Advanced Research and Development Authority (BARDA) initiated several vaccine development projects in support of the overall response efforts. The urgency associated with the epidemic triggered the clinical evaluation of lead vaccine candidates starting in late 2014. Here we will discuss development of the lead vaccine candidates for Ebola virus, specifically Zaire ebolavirus.

Keywords: Ebola; Filovirus; Vaccine.

MeSH terms

  • Disease Outbreaks / prevention & control
  • Ebola Vaccines / administration & dosage
  • Ebola Vaccines / immunology*
  • Ebolavirus / genetics
  • Ebolavirus / immunology*
  • Emergency Medical Services
  • Genetic Vectors / genetics
  • Genetic Vectors / immunology
  • Hemorrhagic Fever, Ebola / epidemiology*
  • Hemorrhagic Fever, Ebola / prevention & control*
  • Humans
  • Public Health Surveillance
  • Vaccination

Substances

  • Ebola Vaccines