Insect C-type lectins in innate immunity

Xiaofeng Xia; Minsheng You; Xiang-Jun Rao; Xiao-Qiang Yu

doi:10.1016/j.dci.2017.11.020

Insect C-type lectins in innate immunity

Dev Comp Immunol. 2018 Jun:83:70-79. doi: 10.1016/j.dci.2017.11.020. Epub 2017 Dec 1.

Authors

Xiaofeng Xia¹, Minsheng You¹, Xiang-Jun Rao², Xiao-Qiang Yu³

Affiliations

¹ State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fuzhou 350002, China; Key Laboratory of Green Control of Insect Pests (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou 350002, China; Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
² School of Plant Protection, Anhui Agricultural University, Hefei 230036, China.
³ State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Institute of Insect Science and Technology & School of Life Sciences, South China Normal University, Guangzhou 510631, China; Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fujian Agriculture and Forestry University, Fuzhou 350002, China; School of Biological Sciences, University of Missouri - Kansas City, Kansas City, MO 64110-2499, USA. Electronic address: yux@umkc.edu.

PMID: 29198776
DOI: 10.1016/j.dci.2017.11.020

Abstract

C-type lectins (CTLs) are a family of proteins that contain characteristic modules of carbohydrate-recognition domains (CRDs) and they possess the binding activity to ligands in a calcium-dependent manner. CTLs play important roles in animal immune responses, and in insects, they are involved in opsonization, nodule formation, agglutination, encapsulation, melanization, and prophenoloxidase activation, as well as in maintaining gut microbiome homeostasis. In this review, we will summarize insect CTLs, compare the properties of insect CTLs with vertebrate CTLs, and focus mainly on the domain organization and functions of insect CTLs in innate immunity.

Keywords: Carbohydrate-recognition domain; Immune response; Lectins; Lepidoptera; Pattern recognition.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Agglutination
Animals
Carbohydrates / immunology
Catechol Oxidase / metabolism
Enzyme Precursors / metabolism
Gastrointestinal Microbiome
Humans
Immunity, Innate
Insect Proteins / genetics
Insect Proteins / metabolism*
Insecta / physiology*
Lectins, C-Type / genetics
Lectins, C-Type / metabolism*
Protein Domains / genetics
Receptors, Pattern Recognition / genetics
Receptors, Pattern Recognition / metabolism*

Substances

Carbohydrates
Enzyme Precursors
Insect Proteins
Lectins, C-Type
Receptors, Pattern Recognition
pro-phenoloxidase
Catechol Oxidase