Dispelling myths about connexins, pannexins and P2X7 in hypoxic-ischemic central nervous system

Abstract

In membrane physiology, as in other fields, myths or speculations may be repeated so often and so widely that they are perceived as facts. To some extent, this has occurred with regard to gap junctions, hemichannels, pannexin channels and P2X7 (ionotropic receptors), especially concerning the interpretation of the individual role of these channels in hypoxic-ischemic CNS since these channels may be closed by the same pharmacological blockers. Significance of existing controversial data are highlighted and contradictory views from different groups are critically discussed herein.

Keywords: CALHM1; Central nervous system (CNS); Connexins; Gap junctions; Hemichannels; Hypoxia-ischemia; P2X7; Pannexins.