Rotavirus Genotypes Circulating in Brazil Before and After the National Rotavirus Vaccine Program: A Review

Pediatr Infect Dis J. 2018 Mar;37(3):e63-e65. doi: 10.1097/INF.0000000000001770.

Abstract

Background: Rotavirus vaccines created the opportunity to control diarrhea in children. We describe the rotavirus genotypes before and after the rotavirus vaccine introduction in Brazil.

Methods: We reviewed the distribution of rotavirus genotypes in Brazil before and after vaccine introduction by searching publication.

Results: Eighty-six studies reported 6884 (15.2%) rotavirus episodes among 45,305 children. Rotavirus caused 22.4% and 11.6% of cases before and after vaccine introduction. G1P[8], G9P[8] and G2P[4] heterotypic strains were most common before and after vaccine introduction.

Conclusions: The vaccines may have selected heterotypic strains in this highly vaccinated population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brazil / epidemiology
  • Genotype*
  • Humans
  • National Health Programs
  • Rotavirus / genetics*
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / prevention & control
  • Rotavirus Infections / virology*
  • Rotavirus Vaccines / administration & dosage
  • Rotavirus Vaccines / immunology
  • Vaccination

Substances

  • Rotavirus Vaccines