Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects

Curr Alzheimer Res. 2018;15(6):531-543. doi: 10.2174/1567205014666171128102557.

Abstract

Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.

Keywords: Alzheimer's disease; acetylcholinesterase; amyloid β-peptide; benzoic acid; butyrylcholinesterase; cinnamic acid; cognition..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Animals
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Cholinesterase Inhibitors / therapeutic use
  • Humans
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / pharmacology*
  • Hydroxybenzoates / therapeutic use
  • Nootropic Agents / chemistry
  • Nootropic Agents / pharmacology*
  • Nootropic Agents / therapeutic use

Substances

  • Cholinesterase Inhibitors
  • Hydroxybenzoates
  • Nootropic Agents
  • phenolic acid