Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

Molecules. 2017 Nov 27;22(12):2073. doi: 10.3390/molecules22122073.

Abstract

The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as Phomopsis sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A-C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against Tobacco mosaic virus (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.

Keywords: Phomopsis; Tobacco mosaic virus; cytosporone; dothiorelone.

MeSH terms

  • Antiviral Agents / isolation & purification
  • Antiviral Agents / metabolism
  • Antiviral Agents / pharmacology*
  • Ascomycota / chemistry
  • Ascomycota / metabolism*
  • Drug Discovery
  • Fermentation
  • Humans
  • Phylogeny
  • Polysaccharides, Bacterial / isolation & purification
  • Polysaccharides, Bacterial / metabolism
  • Polysaccharides, Bacterial / pharmacology*
  • Secondary Metabolism
  • Structure-Activity Relationship
  • Tobacco Mosaic Virus / drug effects*

Substances

  • Antiviral Agents
  • Polysaccharides, Bacterial