Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model

Thromb Res. 2018 Jan:161:22-25. doi: 10.1016/j.thromres.2017.11.015. Epub 2017 Nov 21.

¹ Department of Radiology and Biomedical Engineering, School of Medicine, Catholic University of Daegu, Republic of Korea.
² Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia.
³ Department of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch, Russian Academy of Sciences, Russia. Electronic address: swetlana_e@mail.ru.
⁴ Department of Radiology and Biomedical Engineering, School of Medicine, Catholic University of Daegu, Republic of Korea. Electronic address: jkkim@cu.ac.kr.

No abstract available

Keywords: Activating free tPA; Fucoidan; PAI-1 binding; Reperfusion; Thrombolysis.

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