Approach, Application, and Bioethics of mtDNA Sequencing in Cancer

Mengjia Qian; Claudio Spada; Xiangdong Wang

doi:10.1007/978-981-10-6674-0_3

Approach, Application, and Bioethics of mtDNA Sequencing in Cancer

Adv Exp Med Biol. 2017:1038:23-38. doi: 10.1007/978-981-10-6674-0_3.

Authors

Mengjia Qian^{1

2}, Claudio Spada², Xiangdong Wang³

Affiliations

¹ Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China.
² Shanghai Institute of Clinical Bioinformatics, Shanghai, China.
³ Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China. xiangdong.wang@clintransmed.org.

PMID: 29178067
DOI: 10.1007/978-981-10-6674-0_3

Abstract

Mitochondrial DNA (mtDNA) is more vulnerable to mutations and associated with many solid tumors. Through mtDNA sequencing, we can find useful information on the mutations implicated in diseases and can better define the impact of mitochondrial dysfunction on the process of carcinogenesis. In current article, we will discuss the current approaches of mtDNA sequencing and the challenges we should overcome, their applications in various cancers, and the potential bioethics problems we should face in the application of mtDNA sequencing in clinical diagnosis and treatment.

Keywords: Bioethics; Cancer; mtDNA sequencing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bioethical Issues*
DNA, Mitochondrial / genetics*
DNA, Neoplasm / genetics*
Humans
Neoplasms* / diagnosis
Neoplasms* / genetics
Sequence Analysis, DNA* / ethics
Sequence Analysis, DNA* / methods

Substances

DNA, Mitochondrial
DNA, Neoplasm