Prospect of Using Cell Product for the Therapy of Skin Defects in Diabetes Mellitus

Bull Exp Biol Med. 2017 Dec;164(2):266-268. doi: 10.1007/s10517-017-3970-0. Epub 2017 Nov 25.

Abstract

The effectiveness of autologous cell product in the therapy of skin burn wounds was studied in C57B1/6 male mice against the background of streptozotocin-induced diabetes mellitus. In animals with and without modeled diabetes mellitus, significant decrease in skin defect area was observed after single administration of the cell product (bone marrow multipotent mesenchymal stromal cells, fibroblasts or media conditioned by these cells).

Keywords: bone marrow multipotent mesenchymal stromal cells; cell product; conditioned media; streptozotocin-induced diabetes.

MeSH terms

  • Animals
  • Bone Marrow Transplantation*
  • Burns / complications
  • Burns / pathology
  • Burns / therapy*
  • Culture Media, Conditioned / pharmacology
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / therapy*
  • Fibroblasts / cytology
  • Fibroblasts / transplantation*
  • Male
  • Mesenchymal Stem Cell Transplantation*
  • Mice
  • Mice, Inbred C57BL
  • Multipotent Stem Cells / cytology
  • Multipotent Stem Cells / transplantation*
  • Skin / drug effects
  • Skin / injuries
  • Streptozocin
  • Wound Healing / drug effects

Substances

  • Culture Media, Conditioned
  • Streptozocin