Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba

J Nat Prod. 2017 Dec 22;80(12):3319-3323. doi: 10.1021/acs.jnatprod.7b00679. Epub 2017 Nov 27.

Abstract

Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 μM) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annonaceae / chemistry
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chlorine / chemistry*
  • Cyclohexenes / chemistry*
  • Cyclohexenes / pharmacology*
  • HeLa Cells
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • K562 Cells
  • Uvaria / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Cyclohexenes
  • Chlorine