Abstract
Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.
Keywords:
Pleurotus eryngii; aromatase inhibitor; ergostane; sterol.
MeSH terms
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Agaricales / chemistry*
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Aromatase / metabolism
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Aromatase Inhibitors / chemistry
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Aromatase Inhibitors / isolation & purification
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Aromatase Inhibitors / pharmacology*
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Enzyme Activation / drug effects
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Ergosterol / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Molecular Structure
Substances
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Aromatase Inhibitors
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Biological Products
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Aromatase
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ergostane
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Ergosterol