Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis

Feng Wang; Shiyu Cao; Ruxia Yan; Zewei Wang; Dan Wang; Haifeng Yang

doi:10.3390/s17112689

Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis

Sensors (Basel). 2017 Nov 21;17(11):2689. doi: 10.3390/s17112689.

Authors

Feng Wang¹, Shiyu Cao², Ruxia Yan³, Zewei Wang⁴, Dan Wang⁵, Haifeng Yang⁶

Affiliations

¹ The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. wangfeng@shnu.edu.cn.
² The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. 1000422898@smail.shnu.edu.cn.
³ The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. 15800386391@163.com.
⁴ The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. wangzewei1226@163.com.
⁵ The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. 18817289115@163.com.
⁶ The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China. hfyang@shnu.edu.cn.

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for the discrimination, identification, and potential quantification of certain compounds/organisms. However, its real application is challenging due to the multiple interference from the complicated detection matrix. Therefore, selective/specific detection is crucial for the real application of SERS technique. We summarize in this review five selective/specific detection techniques (chemical reaction, antibody, aptamer, molecularly imprinted polymers and microfluidics), which can be applied for the rapid and reliable selective/specific detection when coupled with SERS technique.

Keywords: antibody; aptamer; chemical reaction; microfluidics; molecularly imprinted polymers; selectivity; specificity; surface-enhanced Raman spectroscopy.

Publication types

Review