Severe Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome-beyond skin involvement

Pediatr Dermatol. 2018 Jan;35(1):e17-e19. doi: 10.1111/pde.13328. Epub 2017 Nov 21.

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious dermatologic diseases with many potential multisystem complications. We describe the case of an 8-year-old girl who developed severe SJS/TEN overlap syndrome (25% of her body surface area was affected) complicated by pancreatitis and bronchiolitis obliterans. These rare complications emphasize the need for careful, intensive monitoring of possible complications and an interdisciplinary team approach to provide optimal treatment and follow-up.

Keywords: drug reaction; mucous membrane disorders; pharmacology; skin barrier.

Publication types

  • Case Reports

MeSH terms

  • Bronchiolitis Obliterans / drug therapy
  • Bronchiolitis Obliterans / etiology*
  • Child
  • Cholangiopancreatography, Magnetic Resonance
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Pancreatitis / etiology*
  • Stevens-Johnson Syndrome / complications*
  • Stevens-Johnson Syndrome / drug therapy
  • Undifferentiated Connective Tissue Diseases / complications*
  • Undifferentiated Connective Tissue Diseases / drug therapy

Substances

  • Glucocorticoids