Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes

Won-Mo Yang; Kyung-Ho Min; Se-Whan Park; Wan Lee

doi:10.1016/j.dib.2017.10.055

Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes

Data Brief. 2017 Oct 28:15:800-804. doi: 10.1016/j.dib.2017.10.055. eCollection 2017 Dec.

Authors

Won-Mo Yang¹, Kyung-Ho Min¹, Se-Whan Park¹, Wan Lee^{1

2}

Affiliations

¹ Department of Biochemistry, Dongguk University College of Medicine, Gyeongju-si, Gyeongsangbuk-do 38067, Republic of Korea.
² Endocrine Channelopathy, Channelopathy Research Center, Dongguk University College of Medicine, Goyang-si, Gyeonggi-do 10326, Republic of Korea.

Abstract

Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-1271 was reported to be upregulated in the liver of diet-induced obese mice (Yang et al., 2016) [1]. In this data article, multiple in silico analysis predicted FOXO1 gene to be a direct target of miR-1271. Dual luciferase reporter gene analysis showed that miR-1271 suppressed FOXO1 expression by direct binding to 3'UTR. The overexpression of miR-1271 reduced the protein expression of FOXO1, thereby reducing the transcription of PEPCK, a downstream target of FOXO1. The data is related to a research article entitled "MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells" (Yang et al., 2016) [1].

Keywords: FOXO1; Hepatocyte; MicroRNAs; miR-1271.