Imaging the Role of Myelin in Concussion

Alexander Mark Weber; Carlos Torres; Alexander Rauscher

doi:10.1016/j.nic.2017.09.005

Imaging the Role of Myelin in Concussion

Neuroimaging Clin N Am. 2018 Feb;28(1):83-90. doi: 10.1016/j.nic.2017.09.005. Epub 2017 Oct 23.

Authors

Alexander Mark Weber¹, Carlos Torres², Alexander Rauscher³

Affiliations

¹ Department of Pediatrics, Division of Neurology, Faculty of Medicine, University of British Columbia, M10 - Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada. Electronic address: alex.weber@ubc.ca.
² Department of Radiology, University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada.
³ Department of Pediatrics, Division of Neurology, Faculty of Medicine, University of British Columbia, M10 - Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada.

PMID: 29157855
DOI: 10.1016/j.nic.2017.09.005

Abstract

Myelin water imaging (MWI) provides mild traumatic brain injury (mTBI) researchers with a specific myelin biomarker and helps to further elucidate microstructural and microarchitectural changes of white matter after mTBI. Improvement of scanner hardware and software with the implementation of MWI across scanner platforms will likely result in increased research regarding the role of myelin in traumatic brain injury (TBI). Future research should include detailed investigation of myelin between 2 weeks and 2 months after injury, the use of MWI in moderate and severe TBI, and investigation of the role of myelin in chronic TBI.

Keywords: Brain; Mild traumatic brain injury; Myelin water imaging; White matter.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain Concussion / diagnostic imaging*
Diffusion Tensor Imaging / methods
Humans
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Myelin Sheath*