Antiviral phenolics from Antenoron filiforme var. neofiliforme

J Asian Nat Prod Res. 2018 Aug;20(8):763-769. doi: 10.1080/10286020.2017.1351437. Epub 2017 Nov 21.

Abstract

Two new phenolics, 1,3-di-O-p-coumaroyl-2',6'-di-O-acetylsucrose (1) and quercetin 3-O-β-D-apiofuranoyl-(1→2)-α-L-rhamnopyranoside (2), along with nine known compounds (3-11), were isolated from the whole plants of Antenoron filiforme var. neofiliforme. Their chemical structures were characterized on the basis of various spectroscopic techniques. This is the first report of the isolation of phenylpropanoid sucrose (1, 3-4) from the genus Antenoron. The bioassay results showed that compound 11 exhibited antiviral activity against the Coxsackie virus B3 (CVB3).

Keywords: var.; CVB3; Polygonaceae; antiviral activity; phenolics; phenylpropanoid sucrose.

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Cell Survival / drug effects
  • Chlorocebus aethiops
  • Cytopathogenic Effect, Viral / drug effects
  • Enterovirus / drug effects
  • Humans
  • Molecular Structure
  • Phenols / chemistry*
  • Phenols / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Polygonaceae / chemistry*
  • Spectrophotometry, Ultraviolet
  • Vero Cells

Substances

  • Antiviral Agents
  • Phenols
  • Plant Extracts