Microfluidics for Combating Antimicrobial Resistance

Trends Biotechnol. 2017 Dec;35(12):1129-1139. doi: 10.1016/j.tibtech.2017.07.008. Epub 2017 Nov 15.

Abstract

The ever-growing threat of antimicrobial resistance (AMR) demands immediate countermeasures. With its novelty and enabling features including downscaled analysis, precisely controlled local environment, and enhanced speed, accuracy, and cost-efficiency, microfluidics has demonstrated potential in several key areas, including furthering our understanding of bacteria, developing better susceptibility testing tools, and overcoming obstacles in discovery and research of new antibiotics. While ample research results in the field of microfluidics are available, their transformation into practical application is still lagging far behind. We believe that the challenge of AMR will give microfluidics a much-needed opportunity to leap from research papers to true productivity, and gain wider acceptance as a mature technology.

Keywords: antimicrobial resistance; antimicrobial susceptibility testing; drug discovery; microfluidics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / chemistry
  • Bacteria / cytology
  • Bacteria / drug effects
  • Bacteria / isolation & purification
  • Bacterial Infections / microbiology
  • Bacterial Infections / prevention & control
  • Bacteriological Techniques*
  • Biomedical Research
  • Drug Resistance, Bacterial*
  • Humans
  • Microfluidic Analytical Techniques*
  • Models, Biological

Substances

  • Anti-Bacterial Agents