Core Clinical Data Elements for Cancer Genomic Repositories: A Multi-stakeholder Consensus

Robert B Conley; Dane Dickson; Jean Claude Zenklusen; Jennifer Al Naber; Donna A Messner; Ajlan Atasoy; Lena Chaihorsky; Deborah Collyar; Carolyn Compton; Martin Ferguson; Sean Khozin; Roger D Klein; Sri Kotte; Razelle Kurzrock; C Jimmy Lin; Frank Liu; Ingrid Marino; Robert McDonough; Amy McNeal; Vincent Miller; Richard L Schilsky; Lisa I Wang

doi:10.1016/j.cell.2017.10.032

Core Clinical Data Elements for Cancer Genomic Repositories: A Multi-stakeholder Consensus

Cell. 2017 Nov 16;171(5):982-986. doi: 10.1016/j.cell.2017.10.032.

Authors

Robert B Conley¹, Dane Dickson², Jean Claude Zenklusen³, Jennifer Al Naber¹, Donna A Messner¹, Ajlan Atasoy⁴, Lena Chaihorsky⁵, Deborah Collyar⁶, Carolyn Compton⁷, Martin Ferguson³, Sean Khozin⁸, Roger D Klein⁹, Sri Kotte¹⁰, Razelle Kurzrock¹¹, C Jimmy Lin¹⁰, Frank Liu¹², Ingrid Marino¹³, Robert McDonough¹⁴, Amy McNeal¹⁵, Vincent Miller¹³, Richard L Schilsky¹⁶, Lisa I Wang¹⁷

Affiliations

¹ Center for Medical Technology Policy, Baltimore, MD 21202, USA.
² Molecular Evidence Development Consortium, Rexburg, ID 83440, USA. Electronic address: dane.dickson@cure-one.org.
³ National Cancer Institute, Bethesda, MD 20892, USA.
⁴ European Organisation for Research and Treatment of Cancer, 1200 Brussels, Belgium.
⁵ Qiagen, Waltham, MA 02451, USA.
⁶ Patient Advocates in Research, Danville, CA 94526, USA.
⁷ Arizona State University, Mayo Clinic, Phoenix, AZ 85257, USA.
⁸ Food and Drug Administration, Silver Spring, MD 20993, USA.
⁹ Cleveland Clinic, Beachwood, OH 44122, USA.
¹⁰ Natera, San Carlos, CA 94070, USA.
¹¹ Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
¹² Merck Sharp & Dohme, North Wales, PA 19454, USA.
¹³ Foundation Medicine, Cambridge, MA 02141, USA.
¹⁴ Aetna, Hartford, CT 06156, USA.
¹⁵ Biocept, San Diego, CA 92121, USA.
¹⁶ American Society of Clinical Oncology, Alexandria, VA 22314, USA.
¹⁷ Genentech, San Francisco, CA 94080, USA.

PMID: 29149611
DOI: 10.1016/j.cell.2017.10.032

Abstract

The Center for Medical Technology Policy and the Molecular Evidence Development Consortium gathered a diverse group of more than 50 stakeholders to develop consensus on a core set of data elements and values essential to understanding the clinical utility of molecularly targeted therapies in oncology.

MeSH terms

Common Data Elements
Consensus
Databases, Nucleic Acid
Genome, Human
Health Information Management*
Humans
Neoplasms / genetics*