Abstract
In this study, we determined the complete coding sequence of a putative new member of the family Flaviviridae, named "Cyclopterus lumpus virus" (CLuV), which is associated with a serious disease in lumpfish (Cyclopterus lumpus). The virus was present in all tissues tested, but pathology was primarily observed in the liver and kidneys. CLuV shows low but distinct similarity to the unassigned Tamana bat virus (TABV). Unlike other known members of the family Flaviviridae, translation of the entire CLuV polyprotein is dependent on a - 1 ribosomal frameshift in the NS2A region.
MeSH terms
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Amino Acid Sequence
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Animals
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Fish Diseases / epidemiology*
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Fish Diseases / virology
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Flaviviridae / classification
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Flaviviridae / genetics*
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Flaviviridae / isolation & purification
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Flaviviridae Infections / epidemiology
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Flaviviridae Infections / veterinary*
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Flaviviridae Infections / virology
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Gene Expression
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Gene Expression Regulation, Viral*
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Kidney / pathology
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Kidney / virology
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Liver / pathology
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Liver / virology
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Norway / epidemiology
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Perciformes / virology*
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Phylogeny
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Protein Biosynthesis
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Viral Nonstructural Proteins / genetics*
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Viral Nonstructural Proteins / metabolism
Substances
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Viral Nonstructural Proteins