A Rare Case of Primary Gastric HIV-Associated Peripheral T-Cell Lymphoma: Relapsed Disease Treated With Pemetrexed

Jun Gong; Maria L Delioukina; Andrew E Hendifar

doi:10.4021/wjon708w

A Rare Case of Primary Gastric HIV-Associated Peripheral T-Cell Lymphoma: Relapsed Disease Treated With Pemetrexed

World J Oncol. 2013 Oct;4(4-5):217-220. doi: 10.4021/wjon708w. Epub 2013 Sep 27.

Authors

Jun Gong¹, Maria L Delioukina², Andrew E Hendifar³

Affiliations

¹ Department of Internal Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, #5512, Los Angeles, CA 90048, USA.
² Blood and Marrow Transplant Program, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AC 1076, Los Angeles, CA 90048, USA.
³ Hematology and Oncology, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AC 1042C, Los Angeles, CA 90048, USA.

Abstract

We present a case of a patient with HIV/AIDS who presented with abdominal pain and melena and was found to have gastric peripheral T-cell lymphoma (PTCL). He was treated with 6 cycles of EPOCH with a complete response. Within 3 months, he had central nervous system (CNS) and soft-tissue relapse. He was subsequently treated with 3 cycles of intravenous pemetrexed and experienced a second complete response. To our knowledge, there are fewer than 100 reports of HIV-associated PTCL worldwide as of 2010, and among these cases involvement of the stomach as the primary site of extranodal disease is exceptionally rare. The disease carries a poor prognosis and current standard therapies highlight the importance of HIV/AIDS disease control and the need for more studies on therapies and the role of transplantation in refractory or relapsed HIV-associated PTCL.

Keywords: HIV/AIDS; Pemetrexed; Peripheral T-cell lymphoma.

Publication types

Case Reports