Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti-Inflammatory Activities

Chem Biodivers. 2018 Jan;15(1). doi: 10.1002/cbdv.201700445. Epub 2017 Dec 27.

Abstract

Chemical examination of a coral-associated fungus Aspergillus versicolor LZD-44-03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A (1) and B (2) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS-induced RAW24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines (MCP-1, IL-6, and TNF-α).

Keywords: Aspergillus versicolor; anti-inflammatory activity; cytokines; structure elucidation; varicuothiols A and B.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / metabolism
  • Alkaloids / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Aspergillus / chemistry*
  • Aspergillus / metabolism
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cytokines / antagonists & inhibitors
  • Cytokines / metabolism
  • Dose-Response Relationship, Drug
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Conformation
  • Nitrites / antagonists & inhibitors
  • Nitrites / metabolism
  • RAW 264.7 Cells
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • Lipopolysaccharides
  • Nitrites
  • varicuothiol A
  • varicuothiol B

Associated data

  • GENBANK/KY744355