Abstract
Chemical examination of a coral-associated fungus Aspergillus versicolor LZD-44-03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A (1) and B (2) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS-induced RAW24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines (MCP-1, IL-6, and TNF-α).
Keywords:
Aspergillus versicolor; anti-inflammatory activity; cytokines; structure elucidation; varicuothiols A and B.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / metabolism
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Alkaloids / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Aspergillus / chemistry*
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Aspergillus / metabolism
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cytokines / antagonists & inhibitors
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Cytokines / metabolism
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Dose-Response Relationship, Drug
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Mice
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Molecular Conformation
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Nitrites / antagonists & inhibitors
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Nitrites / metabolism
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RAW 264.7 Cells
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Structure-Activity Relationship
Substances
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Alkaloids
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Lipopolysaccharides
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Nitrites
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varicuothiol A
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varicuothiol B