Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine

Macromol Biosci. 2017 Dec;17(12). doi: 10.1002/mabi.201700250. Epub 2017 Nov 16.

Abstract

Pseudouridine (Ψ) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first Ψ molecularly imprinted polymer (Ψ-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of Ψ in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.

Keywords: cancer; imprinted polymer; molecular recognition; pseudouridine; tailor-made monomer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / urine*
  • Chromatography, High Pressure Liquid / methods*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Imprinting / methods
  • Polymerization
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Pseudouridine / urine*
  • Solid Phase Extraction / instrumentation
  • Solid Phase Extraction / methods
  • Solvents / chemistry

Substances

  • Biomarkers, Tumor
  • Polymers
  • Solvents
  • Pseudouridine