Evaluation and Management of Oral Potentially Malignant Disorders

Christine Nadeau; Alexander Ross Kerr

doi:10.1016/j.cden.2017.08.001

Evaluation and Management of Oral Potentially Malignant Disorders

Dent Clin North Am. 2018 Jan;62(1):1-27. doi: 10.1016/j.cden.2017.08.001. Epub 2017 Oct 18.

Authors

Christine Nadeau¹, Alexander Ross Kerr²

Affiliations

¹ Faculty of Dentistry, Université Laval, Pavillon de Médecine dentaire, 2420 rue de la Terasse, Québec, Québec G1V 0A6, Canada. Electronic address: christine.nadeau@fmd.ulaval.ca.
² Department of Oral and Maxillofacial Pathology, Radiology and Medicine, NYU College of Dentistry, 345 East 24th Street, New York, NY 10010, USA.

PMID: 29126487
DOI: 10.1016/j.cden.2017.08.001

Abstract

Oral potentially malignant disorders (OPMDs) refer to epithelial lesions and conditions with an increased risk for malignant transformation; oral leukoplakia is the most commonly encountered. Overall, OPMDs have a low risk for malignant transformation, yet the challenge is the difficulty to reliably identify and predict which patients with OPMDs are at the highest risk for malignant transformation. Future research is needed to elucidate the molecular aspects of OPMDs, to improve current diagnostic strategies, leading to personalized management.

Keywords: Leukoplakia; Malignant transformation; Management; Oral potentially malignant disorders; Risk assessment; Screening.

Publication types

Review

MeSH terms

Cell Transformation, Neoplastic
Diagnosis, Differential
Humans
Mass Screening
Mouth Neoplasms / diagnosis*
Mouth Neoplasms / therapy*
Precancerous Conditions / diagnosis*
Precancerous Conditions / therapy*
Risk Assessment
Risk Factors