Action potential propagation: ion current or intramembrane electric field?

Gen Physiol Biophys. 2018 Jan;37(1):71-82. doi: 10.4149/gpb_2017017. Epub 2017 Nov 11.

Abstract

The established action potential propagation mechanisms do not satisfactorily explain propagation on myelinated axons given the current knowledge of biological channels and membranes. The flow across ion channels presents two possible effects: the electric potential variations across the lipid bilayers (action potential) and the propagation of an electric field through the membrane inner part. The proposed mechanism is based on intra-membrane electric field propagation, this propagation can explain the action potential saltatory propagation and its constant delay independent of distance between Ranvier nodes in myelinated axons.

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Cell Membrane / physiology*
  • Computer Simulation
  • Electromagnetic Fields
  • Humans
  • Ion Channel Gating / physiology
  • Ion Channels / physiology*
  • Membrane Potentials / physiology*
  • Models, Neurological*
  • Ranvier's Nodes / physiology*
  • Synaptic Transmission / physiology*

Substances

  • Ion Channels