Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer

Bull Exp Biol Med. 2017 Nov;164(1):95-98. doi: 10.1007/s10517-017-3932-6. Epub 2017 Nov 10.

Abstract

A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.

Keywords: cycle; stomach cancer; genes regulating cell; p53 G215C, p21 A1026G, and G369C; polymorphism.

MeSH terms

  • Aged
  • Case-Control Studies
  • Cyclin-Dependent Kinase Inhibitor p21 / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Stomach Neoplasms / genetics*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • TP53 protein, human
  • Tumor Suppressor Protein p53