Abstract
Three new lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxolup-20(29)-en-28-oic acid (2), and 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), together with eight known compounds (4-11) were isolated from a methanol extract of Phoradendron vernicosum aerial parts. The chemical structures of 1-3 were determined on the basis of spectroscopic data interpretation. The isolated compounds were tested against seven human cancer cell lines and two normal cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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KB Cells
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MCF-7 Cells
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Mexico
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phoradendron / chemistry*
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry
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Plant Leaves / chemistry
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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3alpha,23-O-isopropylidenyl-3alpha,23-dihydroxylup-20(29)-en-28-oic acid
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3alpha,23-dihydroxy-30-oxolup-20(29)-en-28-oic acid
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3alpha,24-dihydroxylup-20(29)-en-28-oic acid
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Triterpenes
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lupane