Abstract
Phytochemical investigation of the stem of Aralia chinensis yielded six new oleanane-type triterpene saponins named as congmujingnosides B-G (1-6). The new ones were elucidated on the basis of the chemical and spectroscopic analysis. Protective effects of compounds 1-6 were tested against H2O2-induced H9c2 cardiomyocyte injury, and the data showed that compounds 1 and 5 had significant cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1-6.
Keywords:
DPPH radical scavenging activity; cardiomyocyte oxidative injury; triterpene saponins.
MeSH terms
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Animals
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Aralia / chemistry*
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Cardiotonic Agents / chemistry
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Cardiotonic Agents / pharmacology*
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Cell Line
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Drug Evaluation, Preclinical / methods
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Hydrogen Peroxide / adverse effects
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Myocytes, Cardiac / drug effects*
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Myocytes, Cardiac / pathology
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Plant Stems / chemistry
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Rats
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Saponins / chemistry
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Saponins / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Triterpenes / chemistry
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Triterpenes / pharmacology*
Substances
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Cardiotonic Agents
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Free Radical Scavengers
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Saponins
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Triterpenes
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oleanane
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Oleanolic Acid
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Hydrogen Peroxide