Abstract
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cystathionine beta-Synthase / chemistry
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Cystathionine beta-Synthase / metabolism
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Cystathionine gamma-Lyase / chemistry
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Cystathionine gamma-Lyase / metabolism
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Humans
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Hydrogen Sulfide / analysis
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Hydrogen Sulfide / chemistry
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Hydrogen Sulfide / metabolism*
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Oxidoreductases Acting on Sulfur Group Donors / chemistry
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Oxidoreductases Acting on Sulfur Group Donors / metabolism
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Sulfite Oxidase / chemistry
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Sulfite Oxidase / metabolism
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Sulfurtransferases / metabolism*
Substances
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Reactive Oxygen Species
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Oxidoreductases Acting on Sulfur Group Donors
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Sulfite Oxidase
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Sulfurtransferases
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Cystathionine beta-Synthase
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Cystathionine gamma-Lyase
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Hydrogen Sulfide