Making Changes: N6-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition

Phillip J Hsu; Chuan He

doi:10.1021/acs.biochem.7b01077

Making Changes: N⁶-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition

Biochemistry. 2017 Nov 21;56(46):6077-6078. doi: 10.1021/acs.biochem.7b01077. Epub 2017 Nov 7.

Authors

Phillip J Hsu^{1

2}, Chuan He^{1

3}

Affiliations

¹ Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago , Chicago, Illinois 60637, United States.
² Medical Scientist Training Program/Committee on Immunology, The University of Chicago , Chicago, Illinois 60637, United States.
³ Department of Biochemistry and Molecular Biology, The University of Chicago , Chicago, Illinois 60637, United States.

Abstract

Zhang et al. (2017) report critical functions of m⁶A during the endothelial-to-haematopoietic transition in zebrafish embryogenesis. m⁶A affects Notch signaling, likely though m⁶A-dependent and YTHDF2-mediated mRNA decay.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / metabolism
Adenosine / pharmacology
Animals
Endothelial Cells / drug effects
Endothelial Cells / metabolism*
Hematopoietic Stem Cells / drug effects
Hematopoietic Stem Cells / metabolism*
Humans
Receptors, Notch / metabolism

Substances

Receptors, Notch
N-methyladenosine
Adenosine

Abstract

Publication types

MeSH terms

Substances

Grants and funding