Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

AIDS. 2018 Jan 14;32(2):267-270. doi: 10.1097/QAD.0000000000001680.

Abstract

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

MeSH terms

  • Cohort Studies
  • Cytomegalovirus Infections / epidemiology*
  • Cytomegalovirus Infections / genetics*
  • Epstein-Barr Virus Infections / epidemiology*
  • Epstein-Barr Virus Infections / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • HIV Infections / complications*
  • Humans
  • Infant
  • Kenya / epidemiology
  • Male
  • Toll-Like Receptor 9 / genetics*

Substances

  • Toll-Like Receptor 9