Scedosporium apiospermum infection of the urinary system with a review of treatment options and cases in the literature

Transpl Infect Dis. 2018 Feb;20(1):10.1111/tid.12804. doi: 10.1111/tid.12804. Epub 2017 Dec 21.

Abstract

Infection with Scedosporium species is associated with a significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy.

Keywords: Scedosporium; bone marrow transplant; genitourinary; kidney; opportunistic infection; transplantation; urinary.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Bone Marrow Transplantation / adverse effects
  • Female
  • Humans
  • Immunocompromised Host / drug effects
  • Itraconazole / therapeutic use
  • Male
  • Mycoses / epidemiology*
  • Mycoses / microbiology
  • Pyrimidines / therapeutic use
  • Scedosporium / drug effects*
  • Scedosporium / isolation & purification
  • Triazoles / therapeutic use
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology*
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Voriconazole