Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves

Jer-Junn Luh; Wan-Ting Huang; Kwan-Hwa Lin; Yi-You Huang; Po-Ling Kuo; Wen-Shiang Chen

doi:10.1016/j.ultrasmedbio.2017.09.010

Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves

Ultrasound Med Biol. 2018 Jan;44(1):214-222. doi: 10.1016/j.ultrasmedbio.2017.09.010. Epub 2017 Oct 27.

Authors

Jer-Junn Luh¹, Wan-Ting Huang², Kwan-Hwa Lin³, Yi-You Huang⁴, Po-Ling Kuo⁵, Wen-Shiang Chen⁶

Affiliations

¹ School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei City, Taiwan, ROC; Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital, Taipei City, Taiwan, ROC.
² School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei City, Taiwan, ROC; Department of Physical Medicine & Rehabilitation, Taipei Veterans General Hospital, Taipei City, Taiwan, ROC.
³ School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei City, Taiwan, ROC; Department of Physical Therapy, Tzu Chi University, Hualien City, Taiwan, ROC.
⁴ Institute of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan, ROC.
⁵ Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital, Taipei City, Taiwan, ROC; Department of Electrical Engineering, National Taiwan University, Taipei City, Taiwan, ROC.
⁶ Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital, Taipei City, Taiwan, ROC; Department of Physical Medicine and Rehabilitation, College of Medicine, National Taiwan University, Taipei City, Taiwan, ROC. Electronic address: wenshiang@gmail.com.

PMID: 29107354
DOI: 10.1016/j.ultrasmedbio.2017.09.010

Abstract

Cavitation plays a substantial role in the clinical effects of extracorporeal shock wave therapy (ESWT). It is also generally accepted as a major mechanism in sonophoresis. To identify the enhancing effect of extracorporeal shock wave-mediated transdermal drug delivery, 24 Wistar rats were randomly assigned to four groups: (i) topical application of a eutectic mixture of local anesthetics (EMLA); (ii) 1-MHz ultrasound; (iii) ESWT pre-treatment combined with EMLA application; (iv) ESWT concurrent with EMLA application on rat tails. The degree of anesthesia was assessed using the amplitude and latency of sensory nerve action potentials within 5 min after a 60-min EMLA application. The results indicated that ESWT pre-treatment and concurrent ESWT accelerated the anesthetic effects of the EMLA cream on the tail nerve (p < 0.05). This finding might indicate that shock wave-mediated transdermal drug delivery is possible during the ESWT period.

Keywords: Analgesic drug; Cavitation effect; Extracorporeal shock wave; Sensory nerve conduction; Sonophoresis.

MeSH terms

Administration, Cutaneous
Anesthetics, Local / administration & dosage*
Animals
Disease Models, Animal
Extracorporeal Shockwave Therapy / methods*
Lidocaine / administration & dosage*
Lidocaine, Prilocaine Drug Combination
Male
Pain / prevention & control*
Prilocaine / administration & dosage*
Rats
Rats, Wistar
Tail / drug effects
Tail / innervation*

Substances

Anesthetics, Local
Lidocaine, Prilocaine Drug Combination
Prilocaine
Lidocaine