Managing Cancer Relapse After Radical Prostatectomy: Adjuvant Versus Salvage Radiation Therapy

Joseph F Rodriguez; Stanley L Liauw; Scott E Eggener

doi:10.1016/j.ucl.2017.07.011

Managing Cancer Relapse After Radical Prostatectomy: Adjuvant Versus Salvage Radiation Therapy

Urol Clin North Am. 2017 Nov;44(4):597-609. doi: 10.1016/j.ucl.2017.07.011.

Authors

Joseph F Rodriguez¹, Stanley L Liauw², Scott E Eggener³

Affiliations

¹ Section of Urology, University of Chicago, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 6038, Chicago, IL 60637, USA. Electronic address: tony.rodriguez17@gmail.com.
² Department of Radiation and Cellular Oncology, University of Chicago, The University of Chicago Medicine, 5758 South Maryland Avenue, MC 9006, Chicago, IL 60637, USA.
³ Section of Urology, University of Chicago, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 6038, Chicago, IL 60637, USA.

PMID: 29107276
DOI: 10.1016/j.ucl.2017.07.011

Abstract

An increasing proportion of men are undergoing radical prostatectomy for locally advanced prostate cancer. More than half of men with adverse pathologic features are expected to experience disease recurrence within 10 years. This article discusses the use of postoperative radiation therapy to decrease this risk. Evidence from 3 randomized trials and multiple retrospective studies indicates that either adjuvant or salvage radiation improve biochemical progression-free survival and may improve overall survival. Novel imaging and genomic analysis can improve patient selection for either modality, however current tests are unable to identify all patients who may benefit from additional local therapy.

Keywords: Adjuvant; Cancer; Prostate; Radiotherapy; Salvage.

Publication types

Review

MeSH terms

Humans
Male
Neoplasm Grading*
Neoplasm Recurrence, Local / radiotherapy*
Patient Selection*
Prostatectomy*
Prostatic Neoplasms / diagnosis
Prostatic Neoplasms / therapy*
Radiotherapy, Adjuvant
Salvage Therapy / methods*