Clonal spread of carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit

J Hosp Infect. 2018 Mar;98(3):300-304. doi: 10.1016/j.jhin.2017.10.015. Epub 2017 Oct 26.

Abstract

Acinetobacter baumannii has often been associated with colonization and/or infection in neonatal intensive care units (NICU). This study describes a clonal spread of carbapenem-resistant A. baumannii (CRAB) isolates in an NICU. In total, 21 CRAB isolates were collected from premature newborns. Only polymyxin B was active against such isolates. Nineteen CRAB isolates were clonally related (Cluster C, which belonged to worldwide-disseminated ST1). All newborns had peripheral access and had received β-lactam therapy previously. The implementation of strict infection control measures was of fundamental importance to eradicate the clonal type in the study hospital.

Keywords: Carbapenem; Colonization; Multi-drug-resistant; NICU.

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter Infections / prevention & control
  • Acinetobacter Infections / transmission
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / isolation & purification*
  • Carbapenems / pharmacology*
  • Case-Control Studies
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Cross Infection / prevention & control
  • Cross Infection / transmission
  • Disease Transmission, Infectious*
  • Female
  • Humans
  • Infant, Newborn
  • Infection Control / methods
  • Intensive Care Units, Neonatal
  • Male
  • Molecular Typing
  • beta-Lactam Resistance*

Substances

  • Carbapenems