Eukaryotic and prokaryotic promoter databases as valuable tools in exploring the regulation of gene transcription: a comprehensive overview

Gene. 2018 Feb 20:644:38-48. doi: 10.1016/j.gene.2017.10.079. Epub 2017 Nov 2.

Abstract

The complete exploration of the regulation of gene expression remains one of the top-priority goals for researchers. As the regulation is mainly controlled at the level of transcription by promoters, study on promoters and findings are of great importance. This review summarizes forty selected databases that centralize experimental and theoretical knowledge regarding the organization of promoters, interacting transcription factors (TFs) and microRNAs (miRNAs) in many eukaryotic and prokaryotic species. The presented databases offer researchers valuable support in elucidating the regulation of gene transcription.

Keywords: Binding site; Database; Gene regulation; Promoter; Transcription factor; miRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Databases, Nucleic Acid
  • Eukaryota / genetics*
  • Eukaryotic Cells / physiology*
  • Humans
  • MicroRNAs / genetics
  • Prokaryotic Cells / physiology*
  • Promoter Regions, Genetic / genetics*
  • Transcription Factors / genetics
  • Transcription, Genetic / genetics*

Substances

  • MicroRNAs
  • Transcription Factors