Sugars have pathogenic roles in diabetes. In Nature Medicine, Zhang et al. revisit this dogma and show that mannose induces the generation of regulatory T (Treg) cells. The immunoregulatory effect of mannose not only prevented the onset of autoimmune diabetes but also blocked disease progression in new-onset diabetic mice.
Keywords: autoimmune disease; fatty acid oxidation; latent TGF-β; mannose; reactive oxygen species; regulatory T cells.
Copyright © 2017 Elsevier Ltd. All rights reserved.