Regulation of ASK1 signaling by scaffold and adaptor proteins

Adv Biol Regul. 2017 Dec:66:23-30. doi: 10.1016/j.jbior.2017.10.003. Epub 2017 Oct 16.

Abstract

The mitogen-activated protein kinase (MAPK) signaling pathway is a three-tiered kinase cascade where mitogen-activated protein kinase kinase kinases (MAP3Ks) lead to the activation of mitogen-activated protein kinase kinases (MAP2K), and ultimately MAPK proteins. MAPK signaling can promote a diverse set of biological outcomes, ranging from cell death to proliferation. There are multiple mechanisms which govern MAPK output, such as the duration and strength of the signal, cellular localization to upstream and downstream binding partners, pathway crosstalk and the binding to scaffold and adaptor molecules. This review will focus on scaffold and adaptor proteins that bind to and regulate apoptosis signal-regulating kinase 1 (ASK1), a MAP3K protein with a critical role in mediating stress response pathways.

Keywords: ASK1; Adaptor; MAPK pathway; Protein binding; Scaffold.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • MAP Kinase Kinase Kinase 5 / genetics
  • MAP Kinase Kinase Kinase 5 / metabolism
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism*
  • Protein Binding / genetics
  • Protein Binding / physiology
  • Signal Transduction / genetics
  • Signal Transduction / physiology

Substances

  • Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase Kinase 5