Neural Circuits Serve as Periscopes for NSCs

Nannan Guo; Amar Sahay

doi:10.1016/j.stem.2017.10.007

Neural Circuits Serve as Periscopes for NSCs

Cell Stem Cell. 2017 Nov 2;21(5):557-559. doi: 10.1016/j.stem.2017.10.007.

Authors

Nannan Guo¹, Amar Sahay²

Affiliations

¹ Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
² Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; BROAD Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: asahay@mgh.harvard.edu.

PMID: 29100005
DOI: 10.1016/j.stem.2017.10.007

Abstract

Neural stem cells (NSCs) within the hippocampal niche integrate local cues, such as activity of inhibitory interneurons, into their homeostatic fate choices. Now in Cell Stem Cell, Bao et al. (2017) describe how these local interneurons relay signals from distal brain regions to govern NSC quiescence and activation.

Publication types

Comment

MeSH terms

Cell Division
Hippocampus / cytology
Interneurons
Neural Stem Cells / cytology*
Neurogenesis*