New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity

Mingxiao Li; Zheyuan Qi; Yimeng Hao; Chongning Lv; Lingyun Jia; Jing Wang; Jincai Lu

doi:10.3390/molecules22111859

New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity

Molecules. 2017 Nov 2;22(11):1859. doi: 10.3390/molecules22111859.

Authors

Mingxiao Li¹, Zheyuan Qi², Yimeng Hao³, Chongning Lv⁴, Lingyun Jia⁵, Jing Wang⁶, Jincai Lu⁷

Affiliations

¹ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. mingxiaoli0928@126.com.
² Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. sevensc@126.com.
³ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. haoyimeng@me.com.
⁴ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. lcnmi@outlook.com.
⁵ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. jialingyun2003@126.com.
⁶ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. wangjingyk@126.com.
⁷ Department of Medicinal Plants, school of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. jincailu@126.com.

Abstract

Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC₅₀ ranging from 24.84 to 37.22 μmol L^-1, which was capable for further drug exploration.

Keywords: Sedum aizoon L.; antitumor; flavonoids; iriflophene.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Furans / chemistry
Furans / isolation & purification
Furans / pharmacology*
Humans
MCF-7 Cells
Magnetic Resonance Spectroscopy
Molecular Structure
Sedum / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Flavonoids
Furans