Neurological update: gliomas and other primary brain tumours in adults

J Neurol. 2018 Mar;265(3):717-727. doi: 10.1007/s00415-017-8652-3. Epub 2017 Nov 2.

Abstract

The emerging understanding of molecular changes in a wide range of brain tumours has led to a significant shift in how these tumours are diagnosed, managed and treated. This article will provide a hands-on overview of the relevant biomarkers and their association with newly defined biological tumour entities.

Keywords: ATRX; Astrocytoma; BRAF; BRAF inhibitor; EGFR; Ependymoma; Glioblastoma; Histone; IDH; MGMT; Mutation; Oligodendroglioma; TERT; Temozolomide; Tumour heterogeneity.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / therapy
  • Glioma* / diagnosis
  • Glioma* / genetics
  • Glioma* / pathology
  • Glioma* / therapy
  • Humans

Substances

  • Biomarkers, Tumor