The relationship between systemic iron homeostasis and erythropoiesis

Gautam Rishi; V Nathan Subramaniam

doi:10.1042/BSR20170195

The relationship between systemic iron homeostasis and erythropoiesis

Biosci Rep. 2017 Nov 29;37(6):BSR20170195. doi: 10.1042/BSR20170195. Print 2017 Dec 22.

Authors

Gautam Rishi¹, V Nathan Subramaniam²

Affiliations

¹ The Liver Disease and Iron Disorders Research Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia nathan.subramaniam@qut.edu.au.
² The Liver Disease and Iron Disorders Research Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

Abstract

Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis.

Keywords: erythropoiesis; erythropoietin; hepcidin; hypoxia; iron metabolism; transferrin receptors.

Publication types

Editorial
Review

MeSH terms

Animals
Cell Hypoxia
Erythrocytes / metabolism
Erythropoiesis*
Gene Expression Regulation
Hepcidins / metabolism
Homeostasis
Humans
Iron / metabolism*

Substances

Hepcidins
Iron